The posed question is about **after** landing on the new planet.

In the given scenario, we're limited by "current technology" and we need to travel by 500 years. Even if the ship's crew is safe, the Earth will have changed, so going back to Earth is worthless.

And it was said that all needed resources are supplied by the ship.

So, the next steps:

1. Mix up (over power?) with local life forms;
2. Create hybrids (dress up?) with local life forms, especially the intelligent ones.

We need to mix up with new life forms, if they're "intelligent", or we can dominate them if they're "not intelligent".

The best way to profit from the new environment's resources is some type of mutation (actually something expected after so many years traveling in space, even in cryogenic sleep).