Assuming that humans could remain as decision-makers at any high level (e.g. defining what type of life humans want to enjoy, what humans would like the world to look like, etc.), the need will always exist to specify (and most importantly give feedback on) those goals, objectives and to keep refining them, or adapt to new preference frontiers.
One could argue that the above constitutes work, and can definitely have both a meaningful and significant impact in the economy, again, subject to the decisions that humans care about and retain control over.
I think we call the above "programming" or machine learning (~ automatic programming from data and problem formulations) in today's world.