This question makes little sense unless you define a bit more precisely what you mean by "pollutants".
As others already said a lot of different substances may be regarded as pollutants in one context and "required food" in another.
I assume You really mean: "is it possible to restore Earth to a status where artificial, man made, products are not detectable?"
Aside from the question if this is really useful or not and also which kind of past condition you want to return to, the general answer is: some kind of damage is permanent, others may be reverted.
One kind of "permanent" damage is what we did by mining (almost) all useful minerals easily accessible (not just fuels) and dispersing them in the ecosystem. Re-gathering all of them from traces is going to be a next-to-impossible task. Another kind, perhaps less "severe" is mountains we (partially) destroyed to cave building materials (again leaving debris, possibly dangerous as asbestos, scattered in almost-unrecoverable particles).
Other may be reversible, with time, energy or both. $C O_2$ pollution can be contrasted with natural (let forests grow and no not use the wood for fire!) or "technological" (pump it some kilometer underground) means.
Cleaning up oceans from all plastic we put there would be a daunting task, but feasible, given time and energy.
Real problem is we cannot even think about repairing damage till we are in the loop of doing even more damage.
First and foremost we should find a way to reduce human population at least by an order of magnitude and we see no way to do that (wars have proven ineffective).
We might have to rely on cleaning-robots after some catastrophic collapse :(