As part of my magic system, the 'life force' is mostly a common 'supernatural' energy produced by most lifeforms (and some minerals can stock/deflect it). This energy allows humans and other human-like beings to control/create magic/summons and increase their stats to superhuman levels, however not all people can withstand the energy consumption of enhancement due of their low 'life energy' levels, causing a multi organ dysfunction syndrome and potential death since they can't regenerate the amount of energy faster enough to continue their normal metabolic processes. This life force mostly flows in the blood like oxygen.
Some people born with higher prana pools and regeneration, and there are a few special persons in the world that have a potential unlimited prana growth, almost predestinated to overcome gods (that's why they're hunted as demons).
But the main topic is not about their powers, but how can I create some common diseases caused by prana problems, like low flow in a limb, or even parasytes, how can I make this life energy affect the biological aspects of human physiology?
One of my ideas is a prana rupture, when an attack hits in a way it cuts the flow and the body starts to lose energy towards the enviroment, but people with higher prana flow would suffer its effects in a higher way.