How likely is the following scenario, and what are add on consequences to such an event happening?
In 1503, when Machiavelli is made head of the Florentine Militia he sets about gaining the talents of Leonardo daVinci to design and produce his weapons of war. By 1505 daVinci is producing the first automobiles and rail roads in Florence.
In 1508 the League of Cambrai formed against Venice, leading to an alliance between Florence and Venice in 1509 with a common goal of routing foreign invaders and establishing secure borders from their common enemies in the League of Cambrai. This alliance eventually lead to the formation of [insert state name] when the fall of Romagna in 1511 to the alliance prompted Modena, Ferrara, and Mantua to petition Florence for protection from Swiss controlled Milan with the same weaponry that they had used to secure their borders and take Romagna.
In 1513, Milan fell to [State] as Louis XII attempted to retake Milan for himself in the battle of Novara, but failed. [State] pushed onwards, reclaiming all former italic land, former french territory up to the Le Rhone, all the Swiss Confederation, and Tyrol by 1516. Corsica and Sardinia joined [State] seeing their growing power in the region and the promise of what daVinci's inventions could do for their importing and exporting of goods.
By 1526 the Pope, Clement VII, had become alarmed by the growing power of the Holy Roman Empire and Spain and attempted to form the League of Cognac, but failed as [State] did not feel threatened. Naples' citizens began revolting against imperial control due to it being weakened by [State's] control of Corsica and Sardinia. Instead, [State] took a neutral stance and allowed either side to pass into their territory so long as they were peaceful in it. This lead to Rome being sacked and Clement being imprisoned by the empire, leaving the Papal States without a leader. By the winter of 1530, both the Papal States and Naples were Annexed into [State].
Francis I took the annexation of the Papal States as offensive act and launched an attack on [State] with the aid of the Ottoman Empire in 1536, but failed due to France's technological inferiority.
In 1542, France once more attacked [State] after a prolonged war with the Spanish and Holy Roman Empire. It was decided by the leaders of [State] at this point France was a nuisance and had to be dealt with. Within 2 years France was conquored by [State] In 1543, the Spanish and Holy Roman Empire was split apart with the treaty of [Treaty], which also officially annexed French holdings to [State].