In One Piece saga there is the so-called Reverse Mountain.
This is a Mountain with sea at east and west, land at north and south.
A river goes from east to west following the mountain. That means that stream goes upwards from east to the top of the mountain and downwards (as it should) from the top to west.
I wonder which kind of weird event could make such a river exist. It should be big enough to be navigable.
Edit: I expect it to have a natural river/mountain. Even though I realize that it might be almost impossible. In that case I feel acceptable to have a technological alternativa that is self-sustaining and uses nowadays technology at most.
Image to clarify.
Edit regarding the question duplicate: In the question it asks about why appears like stream goes upwards in maps. Actually the accepted answer explains how the water goes downwards but appears otherwise. This question asks about water really going against the gravity.