Let's assume that the dictator of a large and rich country is approximately 70 years old, and that signs of old age are showing, meaning that his death is not very far. Let's assume that the people of the country want to keep this person alive for the longest possible period at any price.

Let's assume that the dictator is a healthy person who does not have cancer, is not obese and exercises regularly. All medical and biological resources (bioengineering, genetic engineering, etc...) of a large and rich country are available.

My question is:

  • What is the most effective method to keep the dictator alive for the longest time possible, using modern or near future state-of-the-art medical and biological technology and surgical procedures?

By "alive" I do not mean cryogenics or any other type of stasis - the dictator should be able to live a (largely) normal life and fulfill his duties and obligations.

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    $\begingroup$ Weird. My company's firewall blocks a lot of the research sites for this topic... Anyway, here's some reading material: life extension. $\endgroup$ – Frostfyre May 24 '16 at 18:21
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    $\begingroup$ @Frostfyre - hmm .. what are they trying to hide? $\endgroup$ – AndreiROM May 24 '16 at 18:59
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    $\begingroup$ Are you seeking scientifically valid, (free radical harvesting agents, exercise) believable (stem cell regeneration, backup organs), implausible (gene repairs), or fantastic (regenerative rays, nanite repair mechanisms, brain uploading) solutions? I see "science based" but not "reality check". $\endgroup$ – The Nate May 24 '16 at 23:58

I would say Heterochronic parabiosis. Basically, a young person and an old person share a circulatory system. This means that the factors which make a person young get into the old person along with the dilution of factors which make a person old. One could possibly have young people feed their plasma into the old person to rejuvenate them.

As well, senolytics may be useful, clearing out damaged cells and the factors that they circulate which make people old. See here.

Edit: Heterochronic parabiosis is the procedure of surgically joining two organisms of different ages so that they share a similar circulatory system. Because aging is a systemic disease (it affects all parts), a significant percentage of the factors which govern again are quite often found in one's circulatory system. There are factors which rejuvenate people and keep them young and their are factors which contribute to aging. By linking circulatory systems, the old people get the 'youth' factors, while offloading the 'aging' factors onto the young organism. This leads to the old organism rejuvenating (though it must be said that the young organism gets the short straw as it ages). So inserting blood plasma from younger people -- which some researchers are currently testing or about to test -- may be a way to get a young person old again.

Senescent cells also influence aging. These cells are cells that are dysfunctional but have not been cleared through apoptosis (cell death). They exist in a senescent state where they give off aging factors into the local environment and blood stream. Removing these cells through various chemicals called senolytics has been shown to increase cardiac output and reverse other signs of aging in mice. One could imagine that a person may be given senolytic compounds to rejuvenate them.

Edit 2: I also want to say that one could potentially isolate the factors that make organisms young and basically have a drug cocktail. Such factors like GDF11 show promise to do so. The problem is that there are so many factors which govern aging and youth so coming up with a complete list is very hard and very tricky. You can though, dependent upon how technical you need it to be, say something like 'a drug cocktail to extend aging which included GDF11, blah, and blah.'

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    $\begingroup$ Plinth can you extract the relevant info from your links? We don't need the full rundown, but we don't like to have answers that are dependent on links because links can die. $\endgroup$ – James May 24 '16 at 18:39
  • $\begingroup$ @James Just did. Hope it's sufficient. $\endgroup$ – Plinth May 24 '16 at 19:00

There are a few options for your ailing dictator.

  • Pump him full of nanites that take over most if not all of his body's functions.
  • Do what Plinth said (Heterochronic parabiosis).
  • Upload his mind into a quantum (or any other type that could handle the job) computer.

that's all I can think of for now.

P.S. Why do the citizens of a dictatorship want their (most probably) cruel oppressor to live for ever?!

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    $\begingroup$ The dictator is very popular - a major part of the population agrees with the nationalistic, conservative, traditionalistic views of the government and actually accept the dictator and his decisions; however, he is not necessarily benevolent. $\endgroup$ – MedwedianPresident May 25 '16 at 14:59
  • $\begingroup$ so he thinks for his people, but he still want power, is that it? $\endgroup$ – Warpspeed SCP May 27 '16 at 8:30

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