It's late, so this is a partial answer. Let's first consider the effects of long term low gravity, which are better known, and see if we can work backwards.
Low gravity has lots of subtle, nasty effects on humans, including loss of bone density, leading to brittle bones, and loss of muscle mass. Additionally, there are negative effects on the cardiovascular system and, at least while weightless, digestion.
Even slightly higher gravity would probably lead to a large increase in muscle, and a consequently higher calorie intake. The subject would also have a dense skeletal structure, as is seen in high-impact martial artists. Some negative consequences might be early-onset arthritis, as with people who wear weight belts and jackets improperly.
Another thing to consider is that small accidents would have more serious outcomes, especially in industry and agriculture. Having a 100 lb bale of hay land on you is no picnic, but having a 150 lb bale hit you is much worse, no matter how dense your bones are. And that's just considering a "mere" .5g increase.
People would probably wear lighter and fewer clothes to avoid encumbering themselves, or overheating. They would likely be more comfortable in colder climates, due to the extra work their bodies have to do just to lift their ribcage. Dehydration would also come up more often, due to people being more prone to sweating. There would potentially be a lower fertility rate, due to the extra strain during pregnancy, a time when the ligaments and joints loosen up in preparation for childbirth.
This is really a short list. Changing gravity long term, even by .1g, would have innumerable little effects on daily life. Hopefully this answer at least gets you pondering.