If artificial gravity isn't available then the ship will need to sport a rotating ring or the trip durations drastically reduced. The human body does very poorly in zero gravity situations even for months-long trips in space.
Assuming a 3 year mission duration.
Considerations:
- Food Stores
- Crew living quarters
- Propulsion
- Ship design/shape
- Defensive Systems
Food Stores
Assuming a 2000 calorie diet with macronutrient ratios at 25% Protein, 25% Fat, 50% Carbs.
Basic weights per macronutrient:
- 4 calories per gram of carb.
- 4 calories per gram of protein.
- 9 calories per gram of fat.
500 calories of protein = 125 grams of protein
500 calories of fat = 56 grams of fat
1000 calories of carbs = 250 grams of carbs
Each crew member needs: 431 grams of food per day and 3 kg of drinking water per day.
$0.431 \,\text{kg} \cdot 365\,\text{days} \cdot 3\,\text{years} = 471.945 \,\text{kg}$ or 1 short ton of food for two people for three years. Some reserves will be helpful in the event of an emergency or a bad batch of food.
$1000 \,\text{liters} = 1 \,\text{meter}^3$
$3 \,\text{liters} \cdot 365\,\text{days} \cdot 3\,\text{years} = 6570 \,\text{liters}$ or $6.5 \,\text{meters}^3$
Crew living quarters
SuperMax prison cells in the United States offer everything a lonely captain and engineer will need (in terms of living space). Each cell measures 4 meters long by 2 meters wide by 3 meters high. This compressed space contains a toilet, sink, shower, bed, desk and chair. With hallways connecting these quarters to the bridge and engineering sections, the crew should be able to keep up on any cardiovascular fitness they may have.
If artificial gravity isn't available then a spinning crew quarters will be required to mimic gravity. Failure to provide some form of gravity will result in lawsuits by the captains and crew that the company failed to meet minimum safety standards.
Waste management and atmospheric conditions will need to be controlled too. Equipment areas for these functions will need to be provided for.
Propulsion
Whatever shape the FTL drive requires. Since FTL drives aren't strictly science-based, there's a lot of leeway in how large the drive needs to be along with any fuel supplies required for the drive.
Ship Shape
Since this ship never needs to worry about entering an atmosphere, the shipwrights will want to maximize the ratio of volume to surface area. The most efficient shape for maximizing this ratio is a sphere. However, a continuously curved shape is more expensive than welding flat plates together. An icosahedron is roughly spherical and can be welded from flat hull plates. The shipping company can find a sweet spot between internal volume and hull plate size.
Defensive Systems
If these are required and assuming a spherical hull, point defenses would be placed at the "north" and "south" poles and at 0°, 90°, 180°, and 270° longitude around the equator. This provides consistent firing arcs across all approaches and large zones of overlapping fire.