TL;DR: Depends on how fast you want it to go.
EDIT: Here is a cheerfully illustrated aircraft design guide for Kerbal Space Program (pre-1.0 aerodynamics, but the basics still hold). Explanation of wings is about halfway through; the rest of it tells you about why the other parts of airplanes look the way they do.
Roughly speaking, the amount of wing (wing area) an aircraft needs to fly is proportional to its weight. When flying forward, wings generate lift that makes the aircraft not fall to the ground, and you need more lift the heavier you are.
Of course, this tells you nothing about how the wing is to be shaped. Generally, wide straight wings give you more lift, which is why you see those on old biplanes, WW2 fighters and small recreational planes.
However, as you go faster, they also generate more drag that you need more powerful engines to fight. That is why swept wings and delta wings are being used; they drag less at higher speeds, and in those conditions additional speed makes up for the difference in lift (when flying faster, wings also lift more).
So if it is a large prop plane, it will likely have wings sticking straight out (picture a C-130). If it is a subsonic jet airliner, they will be swept back somewhat; if it is supersonic, it will have a delta wing like Concorde. Faster yet and it will probably rely mostly on body lift.
As for VTOL, a big aircraft would need some pretty powerful engines to do that. What you essentially need to do is start thrusting up with more thrust than the aircraft weighs, then transition into horizontal flight where your speed is sufficient to keep you airborne. Most planes' engines are not powerful enough to lift the weight of the plane, so you'd need some pretty beefy ones; there is a reason why VTOLs to date have either been fighter jets (which have ridiculously powerful engines in order to fly supersonic) or prop hybrids (like Osprey; props aren't as powerful, but can be made much more efficient).