Anabiosis would be easier to implement
Most cold-blooded creatures, likely including your species, are able to hibernate during cold seasons, with their body temperature going below zero Celsius. Although in order to perform interstellar travel such anabiosis would take more than several seasons, your species might survive the journey a lot better than hot-blooded species. This enables that civilization to build sleeper ships with less reliance on machinery, as cryo-sleep could well be a natural condition for the species.
Also this would lower the requirements to energy consumption mid-flight, as deep freezing would not damage the sleeping populace beyond repair. Say, 200K ambient temperature compared to at least 250K for hot-blooded species, this would allow retaining heat aboard with RTGs instead of running a reactor just to heat the ship mid-flight.
A generations ship would have the ability to cryo-conservate in case of major failure
If your species would build a generations ship instead of a sleeper ship, its inhabitants would have a chance at surviving in case of oxygen supply/replenishment failure by employing an emergency "winter", effectively turning the ship into a sleeper one, while a select few crewmembers could still remain heated and supplied with stuff in hopes of fixing the ship up, or at least get waked for deceleration supervision and probably be able to get the ship to orbit the destination star, increasing the expedition's chances of survival and actual colonization, as the populace would be largely available to drop to the surface upon arrival.
Such a ship might also include a "sleeper drone" or several, that would get separated should the main ship come close to an interesting system, that would host a small amount of species in hibernation, get detached from the ship and attempt a computer-powered deceleration towards a detected planet that could potentially be habitable by them. I expect a NIR/MIR telescope to be possibly mounted on the colonization ship to watch for nearby stars, and the initial route to be planned so that the ship would pass at least one extra star system on its way to destination. Building these would be easier for cold-blooded creatures due to the same issue that would allow easier sleeper ships.
I don't see the immediate major changes required for cold-blooded species regarding ship design, with probably one exception: their space stations and generation ships would need to have at least one area being colder than the rest, due to likely adaptation of their brain to be sleeping in colder environment than being active, leading to potential exhaustion should the sleep be not provided with required ambient temperature. Designing that area might include heat projectors to wake up crewmen as needed, an extra space suit layer might be needed that would help gain body heat required for action, and dressing in one would be required before going to sleep, some movable beds could be installed in such place, as cold-blooded creatures sleep immobile, thus the sleeping area could indeed be more densely packed, some planet-based traditions might exist to be transferred to space habitat, etc., but this all is not largely relevant to this question IMHO.
Getting to space would be indeed harder
"Getting to space" actually means the entire civilization development prior to having inhabited modules in space. This is harder for cold-blooded species because of having less time to think about space, as some time would be spent hibernating, also in low season those species would have hard time just moving, making them more vulnerable to external threats. Oases do exist, hydrothermal streams could be used to withstand winter, etc etc, but overall the civlization development would be gradually slower. Also their anatomy might pose an obstacle, as if they might not be able to see the stars to ever desire going up in the first place.