Some psychology studies have already been performed that suggest the human brain is plastic enough that this isn't much of a problem.
One experimenter wore a belt around his waist, a portion of which was always buzzing and letting him know the direction of magnetic north (true north? don't remember, either is possible with electronics). After several weeks he was more than used to it, and claimed that it allowed him to navigate easily in buildings he'd never been in before.
After removing it, he also claimed that it felt in some way as if he were blinded. A sense of being lost, disoriented, and so forth lasted for days.
Other senses involve putting small permanent magnets in one or more fingertips. I have no idea why someone would do this, but apparently you can touch (the insulation of) electric wires, and know whether these are hot (have electricity flowing through them) because it produces a slight tingling sensation. Though it might be interesting and useful to have that as an electrician (so you don't electrocute yourself), seems like it might be more dangerous (fingertips are even more conductive). I have no idea why anyone else would bother. But supposedly this works too.
Many people have their sight or their hearing restored, or in some cases they will have it given to them for the first time. Surgeries and other medical interventions now sometimes border on the miraculous. They do tend to have some trouble, but it's generally social (the deaf population can sometimes be in opposition to cochlear implants, etc).
Sometimes, even new senses can be be conferred... some eye surgeries allow people to see into the near-UV spectrum. Apparently our retinas are more than capable of perceiving this light, but our corneas are pretty opaque to it.
(Though mild,) Real-world examples abound. The best we can tell, it takes a few days to a few weeks to acclimate, and then the person feels as if it's almost the case that it's always been that way. Minimal adjustment is needed, and isn't in any way uncomfortable.
Except for possibly growing taste buds in your rectum. The studies haven't done much to clarify how that affects a person.