I have been wondering how galactic features could impact interstellar civilizations in the process of colonizing a galaxy (either andromeda or the milky way).
According to this video these features, specifically the arms and the core, could be areas in which life would have a harder time developing due to stellar activity and radiation, but I can't help but wonder if they'd also be obstacles for spacefaring and interstellar civilizations.
Additionally, the interstellar civilizations in my universe have access to FTL technology but it requires very precise calculations and conditions in order to be exploited not to mention that generally it can only be used to jump only to nearby systems due to energy constraints.
So with these considerations, would these features be relevant obstacles?