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In a live-action musical film I want to direct, Le Président et Moi (I want the film to have French as its original language), there is a character named Édouard Wang. They (Wang is a closeted non-binary assigned male at birth human being) has the following physical features:

  1. Despite being a 22 years old adultescent (or kidult, if you want), a genetically, and biologically male human, Wang does not have any facial hair.
  2. Despite being 2.00 metres tall and weighting 160 kilograms (they has both proportional gigantism like Hulk Hogan and massive obesity like John Candy), Édouard Wang has a raucous high-pitched voice (a raspier version of Jar Jar Binks' voice from Disney/Lucasfilm's Star Wars, but without saying weird words).
  3. Finally, Édouard Wang is multiracial: their paternal grandfather was a Han Chinese, their paternal grandmother was a White Frenchwoman, their maternal grandfather was a Tahitian, and their maternal grandmother was a Marquesan (so, they is one fourth Caucasoid, and three fourths Mongoloid according to old race and ethnicity classification) (Wang lives in the Fifth French Republic, in French Polynesia to be exact).

So, I wonder if there is a genetic disease that makes genetically and biologically male human beings having the two physical features written at the top of the list (in other words, being a tall and obese person, but having a raspy high-pitched voice, and do not having the ability to grow sideburns, a goatee, and a moustache).

Note: I have mentioned Wang's ethnicity, because Mongoloids (such has Chinese people, Austronesians, Japanese people, and Amerindians) tend to be the most glabrous members of the Homo sapiens species, and at the opposite, Caucasoids (such has Armenians, Jews, Egyptians, Pakistanis, and White French people) tend to be the hairiest members of the Homo sapiens species.

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    $\begingroup$ Not long enough to consider an answer. But couldn't you just handwave it and say they inherited a 'non-hairy' gene, and leave it at that? There are western AMAB that are 'hairless', so it's not that weird a concept. $\endgroup$ Jun 10 at 0:35
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    $\begingroup$ Technically speaking, a genetic something-or-other that really only prevents male facial hair is not a "disease", but rather is a Godsend! Home run if it also reduces or eliminates general hairiness and eradicates male pattern baldness. $\endgroup$
    – elemtilas
    Jun 10 at 4:57

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Klinefelter syndrome, Syndrome de Klinefelter (AKA. "47,XXY")

A genetic disorder where the number of X chromosomes (the sex-chromosome usually paired with another X in females or a Y in males) is increased above the normal two for women and one for men. It's quite rare comprising only 4 out of 10,000 males. In men there can exist 3 Xs, and very rarely as many as 4 Xs along with a single Y chromosome.

Broader hips, a tendency to rounder body-shape, symptoms may also include weaker muscles, greater height, poor motor coordination, less body hair, breast growth, and less interest in sex. A normal or near-normal life expectancy is present, occasionally children may be conceived naturally, but usually only with medical intervention.

There's another condition: Alopecia areata (Pelade en française). Bald-spots the size of a large coin can appear anywhere on the body/head. It's thought to occur as a stress-response in predisposed individuals. Though it doesn't spread by itself, increased stress will increase hair-loss. May be accompanied by cicatricial alopecia, rendering the hair follicles permanently inactive due to sub-cutaneous scarring. Events such as a car-accident, bereavement and presidential crises might well be a trigger for patches to appear.

If you really want to pile-on the bad-luck, they could also suffer from alopecia universalis (alopécie générale - a genetic predisposition thought to be possibly triggered by exposure to some complex organic chemicals), which would render them completely hairless, anywhere on the outside of their body.

I'll leave it to the OP's discretion to decide what might suite the story best (or be able to be rhymed with).

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