I wonder if the disease I invented is realistic or a total fiction.
In a white drama/lighthearted tragedy (the opposite of black comedy/dark humour) web-series for a teen audience in mind I want to create, The Transcendence of Adolescence, there is a 13 years old asexual transgender man named Adolfo Pedro Ramirez that has a strange genetic disease: he is completely unable to produce adrenaline (or epinephrine, if you want). Because of his bizarre syndrome, A. P. Ramirez is stoic as a cat (which is somewhat ironic, because both humans aged from 2 to 5 years old and humans aged from 10 to 17 years old are famous for being extreme mood-swingers). What I mean is he is unable to feel anger, and has no known phobias, but at least, he still can feel sadness, disgust, and joy (I said he was a trans man, so he was gender dysphoric, and by extension, he was often sad and disgusted before transitioning) (sorry for my Disney/Pixar's Inside Out reference).
If this genetic disease exists, what is its mode of inheritance? Autosomal dominant (like type 1 von Willebrand disease), autosomal recessive (like cystic fibrosis), X-linked dominant (like X-linked pituitary gigantism), X-linked recessive (like Hunter syndrome), incomplete dominance (like myostatin-associated muscular hypertrophy), or mitochondrial (like Leigh syndrome)?
If this is autosomal, what chromosome is linked? Chromosome 1 (like Hutchinson-Guilford progeria), chromosome 2 (like Ehlers-Danlos syndrome), chromosome 3 (like retinitis pigmentosa), chromosome 4 (like achondroplasia), chromosome 5 (like Sotos syndrome), chromosome 6 (like hemochromatosis), chromosome 7 (like tritanopia), chromosome 8 (like Werner syndrome), chromosome 9 (like cartilage-hair hypoplasia), chromosome 10 (like type 2 multiple endocrine hyperplasia), chromosome 11 (like sickle-cell anaemia), chromosome 12 (like phenylketonuria), chromosome 13 (like Wilson disease), chromosome 14 (like Krabbe disease), chromosome 15 (like Marfan syndrome), chromosome 16 (like Morquio syndrome), chromosome 17 (like type 1 neurofibromatosis), chromosome 18 (like type-C Niemann-Pick disease), chromosome 19 (like Donohue syndrome), chromosome 20 (like adenosine deaminase deficiency), chromosome 21 (like autoimmune polyendrocrinopathy-candidiasis-ectodermal-dystrophy), or chromosome 22 (like type 2 neurofibromatosis)?
I know I made an extremely long enumeration because the vast majority of the human genome is nuclear and autosomal, sorry.
Naturally, except for being more or less Zen, what would be the health consequences of being unable to produce adrenaline? Would people with this genetic syndrome be resistant to noninfectious heart diseases? Therefore, would they live longer?
