Stolen shamelessly from one of my previous posts.
If you absolutely, positively need to sterilize the surface, you must blast it from orbit. It's the only way to be sure.
The problem you'll quickly run into is that the Earth is big. You can crash 10km sized asteroids into it, and there'll still be some survivors to whine about the injustice of it all. Now, we wouldn't want that, would we? There are two surefire ways.
1. Antimatter Bombardment
No, the only way to be sure is to be thorough. You'll need a fair bit of antimatter, um, let's see...
1 Mt is $4.1\times10^{15} J$ so the Tsar Bomba (in the tested config) at $42MT = 1.72 \times10^{17} J$
2 kg of $E=mc^2 = 1.79 \times 10^{17} J$
So each 1 kg antimatter bomb (as it anihillates with 1kg ordinary matter) would have a blast similar to the Tsar Bomba, the most powerful nuclear device ever detonated in the puny humans' history. That gives you a nice $1,200 km^2$ blast incineration area. Now, if we were sloppy, we would just pepper the land area of $148,300,000 km^2$, so about 1,236 MIEVs (Multiple Independently Targetable Entry Vehicles) with 100 1kg (+containment) warheads each would do.
But that would miss all the boats, planes and submarines crowding their primitive buoyancy based transportation lanes. With about 100,000 ships out there, that's a lot of survivors. $361,000,000 km^2$ to cover, you'd need another 3,009 MIEVs. You might still miss a submarine or two, but without space launch capabilities, zero industrial capacity, and an all-male crew, you're set anyway.
Pro: Clean blasts, little of that nasty radioactive slag. Also, once in atmosphere, any attempt to shoot down will only damage the containment system and detonate the antimatter.
Con: You need a lotta bombs.
2. A dozen or more relativistic ships.
Thanks to our friends at Wolfram Alpha, I don't even have to do the calculation myself. Take your standard light-crafts, a 3,000 ton craft, push them to a reasonable 0.25 c and crash them on opposite hemispheres (preferably from multiple directions, but you could also do several hours apart). Each will clock in at around $8.8\times10^{21}J$, or about 10,000 times those anti-matter firecrackers from earlier, or about the same as a 10 km asteroid impact. To be really sure, send a few dozen of these.
Pro: Almost impossible to intercept once acceleration is complete.
Con: Your reptilian colonists awaiting in orbit might themselves cook a bit from the impact gamma blasts.