I have been reading about Complete Androgen Insensitivity Syndrome and from what I understood these women have features like being more beautiful and more attractive than the average, lack of periods, it is impossible for them to develop menopause,they cannot get ovarian and womb cancer, they are infertile.

In a world that already have billions of people and people can reproduce using stem cells and artificial womb infertility is not an issue. I read that they have a small change of developing gonadal cancer but many doctors still recommend them to get gonadectomy.

  • $\begingroup$ Well, humans have given up a lot of skills that where once vital, but which technology allowed us to loose as usually better solutions came around. Just look at the fitness of an average hunter-gatherer. So why not. While I think this question will get closed as option-based, there is a solid chance that self modification of this kind will be fairly normal in a few centuries or even decades. Considering the possible diversity of humanity (think of mind-uploading, uplifting of animals and cyborgs), this is rather simple and conservative (from a possible future perspective). $\endgroup$ Jan 29, 2022 at 16:16
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    $\begingroup$ I'm unsure how this is post is about building a fictional world. As written you brought up a hormonal condition you've read about and your fascination with dating someone with this condition. Where is the fictional world you are trying to build? What issue are you having building it? $\endgroup$
    – sphennings
    Jan 29, 2022 at 17:50
  • $\begingroup$ Why would many parents choose for this ? Would there be many ? How many ? I wonder if this is answerable (in the first place) and I have the impression you somehow try to put a question in "worldbuilding style" with a description that has no worldbuilding aspects. You are talking humans, Earth, 21st century insights. If you want to focus on the positive aspects of this pathology, you;d better post a question about that first.. are there positive aspects ? medicalsciences.stackexchange.com $\endgroup$
    – Goodies
    Jan 29, 2022 at 19:03
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    $\begingroup$ You're looking at this question from the perspective of "society." Sure, "society" might favor doing it because of the reasons you state. But would one set of parents choose to give up grandchilden just to avoid uncommon cancers and have a temporarily more beautiful child? I'm no expert, but my psychology spidey-sense says very few people would choose to willingly alter their child from its biological norm. (*Continued*) $\endgroup$
    – JBH
    Jan 30, 2022 at 19:46
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    $\begingroup$ Although if you really want to get the political fires burning, let's ask this question from the opposite perspective, and ask how many parents would choose, if the tech existed, to guarantee their child was heterosexual and cisgendered? This might be an interesting study in psychology - under what circumstances would the average set of heterosexual parents choose to alter an unborn child away from the biological roll-of-the-dice they were given? $\endgroup$
    – JBH
    Jan 30, 2022 at 19:47

1 Answer 1


From what I gathered ; women with androgen insensitivity range from normal looking to really manly, displaying a facial structure that looks like an actual man. Might just be a coincidence.

As of being unable to get ovarian cancer, impossible. No biological tissue will ever be immune to cancers, in fact even the tissue covering your eyes is developing cancers at a rate of millions per day, same goes with all your body parts ... fortunately they are killed and replaced, until some day your body will let one or more slip by.

Women with this syndrome have less ovary tissue among other things, but that space is still replaced by other bodily cells, so overall no change in cancer rates, it only changes where they happen.

Cancer is never a question of "will I ever get cancer?" But a question of "will I live long enough to be killed by cancer?"

Virtually 1 young adult in his 20's out 3 has developed at least a few small tumors in their body that could become lethal in certain situations some times in the future

The health malfunctions are outweighting whatever advantage they might get.

If you don't like your menstrual cycle, there's pills for that, no need to be born infertile and a risk of an early death.

Let's also not forget that hormones are important to brain development and plasticity, hormones are specially often used to treat behavioral misshapes and brain defects.

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So would many parents choose that over natural healthy children? Maybe but only due to ignorance and some propaganda, are you trying to write a dystopian story?

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    $\begingroup$ I really wonder if the first sentence of this answer is correct ? "women with androgen insensitivity range from normal looking to really manly" how come ? androgen insensitivity will inhibit the workings of male hormons, a woman with this syndrome will look female, a male with this syndrome will also look female. Check out the Wiki topic, en.wikipedia.org/wiki/Complete_androgen_insensitivity_syndrome $\endgroup$
    – Goodies
    Jan 29, 2022 at 18:55
  • $\begingroup$ This syndrome effects both XY (genetic males) and XX (genetic females) differently, it is perhaps important for understanding to differentiate clearly between the two rather than lumping them together without differentiation as you and the asker have, the effect on the development of XX individuals is relatively minimal and does not result in infertility, they are effectively the conditions carriers passing it to their offspring, XY individuals with it have internal testis in place of ovaries and are considered to be subject to a higher incidence of testicular cancer than other XY individuals. $\endgroup$
    – Pelinore
    Jan 31, 2022 at 11:20

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