An unarmed, unarmoured, unprepared human against a large apex predator? That can be expected to hunt in packs? That's a fairly clever hunter? That eats things that are substantially bigger, stronger, faster, tougher and more dangerous than humans?
Your best bet is to offer it a limb you don't need as much... your off-hand, perhaps. If you're lucky, it won't like the taste of you very much, and will give up. If you're really lucky, it'll choke on some of the splintery little bones, but I wouldn't pin my hopes on that. It is at least slightly more likely than plan B, which is hope that a tree falls on it.
What weak spots in a wolf can be severly [sic] damaged without weapons and cause the wolf to run away or be defeated?
The same weak points that any predatory mammal has. Realistically though, you will simply not be able to hit them... you are a naked ape, with limited capacity for resisting teeth and claws, you have no useful natural weapons, and you're trying to go one-on-one with an actual killing machine. You know how you don't hear many stories about people kicking bears in the balls, or poking tigers in the eyes, and escaping to tell the tale?
There's a reason for that. Don't fight apex predators on their own terms. You gonna get et.
(also, even if you did somehow manage this miraculous action, this is a pack animal, and do you really think you're gonna pull it off more than once? against multiple opponents? nope)
Consider though, it might not actually attack you. You're a funny shape, and a funny smell. You aren't much like its regular prey. Wolves aren't stupid. It isn't going to just charge in and attack immediately like a computer game random encounter. If it has rabies, it'll behave as you're asking, and then you're SOL (and even if you did survive, you've probably just contracted a deadly virus, yay!)
Your only hope is that it reacts like a normal, healthy wolf, and you're able to back away, take stock of the situation and start equipping yourself with the tools you need to survive. Cos without them, you won't.