It can depend a lot on what lizard or lizards you used
You see, lizards are a very, VERY diverse group. It includes from the gecko to the Komodo lizard and different lizards evolved to fill different niches in different habitats, so let's see some traits of various lizards to see what can be done (I will note though that I'll use mostly traits observed in the komodo dragon, due to its size, and in other monitor lizards, and I greatly suggest you check this video for more ideas):
1-teeth: yeah yeah, you said you wanted out of the cliches, but unless you want to add in magical powers, you'll have to stick to some of them, because claws and teeth are the main weapons of several lizards. A lizard-like head the size more in proportion to a humanoid body like you mentioned will easily be the size of a komodo dragon, and while their bite isn't the most brutal you'll find out there, their centimeter long serrated backwards pointing teeth will do a number on your flesh of it gets to bite you (especially since they don't just bite, they bite and pull, slicing and tearing the flesh), with additional damage being dealt by a second trait you can have:
2-Venom: various species of lizard, including the komodo dragon, are known to possess venom, which seeps through the teeth into wounds created by their bite. The venom is nothing like the one found in the cone snail and is slow-acting, but it can prevent your blood from clotting and lowers your blood pressure, aka that bite you suffered a few hours earlier that didn't seem like anything too bad? It's not gonna stop bleeding like a normal cut, and the bacteria, while not nearly as critical, will still make it worse, putting you at risk of blood poisoning, not that you'll have to worry about it unless you stop the bleeding before you go into shock. Also, you haven't escaped yet, because your foe has another advantage.
3-enhanced olfactory capabilities and sight: Komodo dragons have an incredible sense of smell that allows them to smell carrion up to 4 kilometers away, which they often used to find the corpses of the inhabitants of the island (which is an actual issue they face, having to take extra measures to ensure the dead stay buried) and the prey they let escape after giving them a proper bite. Thanks to this, they don't need to worry about letting their prey escape, because they can just track them, patiently waiting until their prey can no longer fight back. Monitor lizards can also spot prey from up to 300 meters, so your lizard warrior can also see pretty well.
4-claws: yep, back to the basics. Monitor lizards use their powerful claws to a variety of tasks, from inflicting damage to competing males and prey, to climbing trees and to dig both for carrion and to make places in which they'll lay eggs. Your lizard person, with enough strength and durable claws, could potentially use them both to fight and to climb surfaces, giving it greater control over the terrain, especially in a forest with large trees.
5-Parthenogenisis: remember how your mage made your lizard person a female and then abandoned it? Yeah let's just say it's potentially no longer alone. Be it due to their lifestyle and aggressive behavior or other factors, Komodo dragons can reproduce via parthenogenisis, aka the females can lay eggs which give birth to males, which can mate with the female to produce more eggs, which makes both more males and females and I think you get the grasp. While it can result in problems related to inbreeding in the long run, for now you still have to worry about the fact that there's more than a single lizard, and if most of the human intelligence and tendency of hunting in groups stayed, you might be more screwed than you know.
5-armor: komodo dragons possess a group of complex osteoderms under their scales, which basically funcion like a chainmail made of bone covering the majority of their bodies. Why do they have it? Most likely to protect themselves against other komodo dragons, point is: below their scaly hide, they have natural chainmail to protect themselves from other members of their species, and so it'd make sense that your lizard people made for combat would also have armor.
6-a more realistic camouflage: a last visit to cliche Town, the ability to turn completely invisible is not something you can get with normal biology, with the closest being an animal that's mostly transparent. However, komodo dragons hunt primarily using stealth, and so it's no wonder if your lizard too was similar in color to its surroundings. It won't make them disappear like an octopus, but it will allow them to get a free first attack if your players don't roll a good enough perception check.
7-Ectothermy: while being cold blooded naturally means you hate winter days, if you live in a tropical region where the cold is not a major problem you'll have one main advantage: you're not having to spend energy to stay warm, and you can naturally go longer without food before you starve to death, meaning you can afford to let your prey escape and wait until the venom does its job without having to fight an unnecessary battle.
Now, is it realistic that you could splice genes between a human and a lizard to get a humanoid creature with the best of both worlds? No, not by a long shot, but the guy who made the thing is a mage, so we can automatically write off all problems with this without having to use a semi-magical virus or anything similar.
The result/potential lore: your mage simply deemed the komodo-monitor-humanoid a failure because it couldn't lift a carriage and thus just trapped her away and essentially forgot about her. After a few months he wondered what had happened to it, and went to check out, only to find that the experiment had dug its way out through the wooden floorboards. He tries to find the animal in the dense woods that surround his secret lab, only to step on something that makes a cracking sound.
He stepped on egg shells, and the owner of those shells spring from nearby, giving him a vicious bite. He escapes and runs, but the lizard seems smaller. He doesn't give much thought and locks himself in his lab. He patches the wound (because realistically forcing his would to heal with magic would make it heat up drastically), but the bleeding won't seem to quit. He starts to get agitated and somewhat distant, but ignores it and goes back to work. A few hours later he's on the floor, his skin pale and his consciousness fading to the point he can't even muster the strength to cast a single spell. That's when a small group of monitor people invade the lab through the tall windows. They bit, they waited, and now, they'll eat.