I watched a video or read some article recently on the reality of Attack on Titan's 3D maneuvering gear (very sorry, but I can't find it) and how it would kill the user easily.
Basically, even with the harnesses that the survey corps use to redistribute weight to the legs and torso, any movement that sent the user vertically (relative to their own body, not gravity) at high speeds would easily kill them due to the Gs, and the incredible centrifugal force of taking a turn at speed would likely snap the leg(s) of the user.
Assuming here that the bones and muscles were already strengthened to handle the crushing and pulling forces on the body, what modifications to the human body (genetic or cybernetic) would need to be made to let a human withstand other issues caused by high G forces and centrifugal force? For example, the increasing weight of the blood in your body as you accelerate.