OK, my last entry. This one includes large & unconventional methods of getting rid of things.
if you absolutely positively have to make it go away, nuclear is the sure fired way to ensure that happens.
The problem of course is how do you keep it from destroying the nearby stuff that you don't want destroyed. Well the US Air Force as an app (project) for that, it's called Casaba Howitzer and it is a freaking nuclear shaped charge.
Size of thing to be destroyed? Roughly human sized
Composition of thing to be destroyed? Most non-refractory materials
Level of destruction? Burn, melt, or vaporize
Proximity to nearby objects? Minimum of tens of feet,
maximum out to hundreds of yards
How affects nearby things? Combustion to dozens of feet,
blindness to anyone who can view the target
How much time? Microseconds
I am tired and don't want to get into all the gory details (but find the topic terribly interesting). Scientists felt they could focus about 80% of the destructive power of the bomb.
That still leaves 20% of a nuclear bomb to annihilate everything else not in path of the directed shot.
Within some (very short) distance of the bomb, the gamma rays and neutrons are powerful enough to cause transmutation (fission & fusion reactions). All chemical bonds will be broken all atoms will be ionized (possibly multiple times).
Within a longer (but still short) distance of the bomb, the heat caused by absorbed gamma rays and neutrons will ensure most chemical bonds are broken and many atoms are ionized (but no nuclear shenanigans will be going on).
In an atmosphere these two zones combine and form the fireball region which absorbs most gammas, causing the air to heat and generate the blast wave.
In space, the gammas just keep going and kill people directly.
Regardless of the direction of the blast, the bomb will spew neutrons about. Neutrons are not stopped very well by most shielding (it's better to use large quantities of water to shield you instead of dense metals, for instance). Neutrons will kill people so even if infrastructure survives the 20% of the bomb that escapes the directed blast, the nearby people will die anyway.
I want to throw one final thought out there.
You could do it with a hypersonic kinetic projectile. If shot from space, it would look like a shaft of light shot down from the sky and simply left a crater where the offensive tidbits were left. The blast from any bombardment which creates a crater will also damage the things around the crater rim. But this sort of strike does not cause radiation damage (but does cause a blast).
Kinetic weapons scale better than conventional or nuclear weapons. They can be as small as a .22 bullet to as large as the dinosaur killing asteroid (~6 miles in diameter). You can also adjust the speed of the projectile.
Kinetic projectiles have the added benefit of not emitting lethal radiation, so if you survive the impact and subsequent blast, you'll survive the encounter.
This a video of the meteor that fell over Russia. Imagine a targeted strike intended to take out a building. It would damage nearby buildings but leave most of the city untouched (sans windows, of course).
Video of meteor over Russia