Say we have an intelligent species whose body plan is inspired by walking insects (ants, beetles, etc.) and reptiles (particularly lizards).
More specifically, let's say they have four legs (I think they'd have things a bit easier with six, so I'll ask the four-leg case, because if it's solvable, six legs also should be) in a sprawling posture. Their legs don't come from the 'corners' of the torso like a vertebrate; their hips and shoulders are closer together, more like an insect (again, to make this the more difficult case). They're smaller than humans (exactly how much not defined at this point). Like an insect or a gecko, they're good climbers. In their case, all feet can grip, and thus they can use them interchangeably as hands. Like most of the animals that inspired them, they have a wider field of vision than a human, which probably helps when doing things with their back feet. They're more like a reptile than an insect insofar as their mouths aren't adapted for carrying things. And no, no prehensile monkey tail.
So, while they have the manipulatory ability to do various tasks and use tools, they seem to have some disadvantages to developing tools and civilization. How do they deal with...?
While they have hands, they don't have dedicated hands. They cannot walk on two legs. Stable standing requires at least two diagonally opposite legs, so other than when sitting / lying down (which are the same thing for a non-erect species), they can't pick up more than two things at once, and using two hands to pick up one object is difficult-to-impossible. Most critically, they can't spare a foot to use as a hand while walking. Moving on two legs is impossible, three is slow and awkward at best.
Their sprawling posture and limited ability to even rear up usefully (shoulders are close to hips) means they can't reach much above themselves. More critically, they can't reach their own backs. Thus, righting themselves if they land on their back is difficult; if they don't have something to grab for leverage, it may be impossible. This also makes their problem carrying things even worse, because while they can carry large loads on their backs, they can't place an object there unassisted!
So, how will their development of tools, transportation, and so on, differ from ours?
(I've seen Could These Two Types of Reptiles Overcome Carrier's Constraint? and How could my non-bipedal intelligent species advance technologically? Neither question or answers address exactly this situation.)