I've been thinking about this for a while, and was so glad to discover this forum exists!
Humans aren't going to be around forever. But how will we actually get wiped out?
Even the Chicxulub impact event that wiped out the dinosaurs ~66 million years ago only extincted ~75% of living species at the time. But humans have tools and technology. We have a huge number of underground bunkers, tons of preserved food and bottled water. We are resilient and adaptive. What kind of event could happen that would actually kill off all humans on the planet?
Pandemic: not a chance. Too many people live in geographically isolated regions and could wait it out.
Nuclear war: not likely. Still too many isolated regions (Pacific Islands, Iceland, Arctic Canada) would avoid the worst effects of initial strike + radiation and could wait it out.
Asteroid hit: this is the most likely extinction event. But even here, there are enough bunkers and preserved food that I'm sure a small number of hardened survivors could survive underground for a few years and make it through.
So what's the end game? How will we actually get wiped out?