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I have read unlimited news in which a person has knowingly laced the food items of a person with something to make him mad to fulfill an ill purpose like succession of property, frustration due to failure in love, etc...

What are such substancecs?

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    $\begingroup$ Alcohol is the most common, unless you're talking about permanent effects. $\endgroup$ – nzaman Oct 6 '18 at 11:23
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    $\begingroup$ What do you mean by "calm mad"? Also, can you explain how this relates to world-building? $\endgroup$ – F1Krazy Oct 6 '18 at 11:30
  • $\begingroup$ @F1Krazy check the last paragraphs of my answer... Usually, when you find someone who has lead poisoning, you may be sure to find thousanda more around. Also, this relates to finding a source of contamination that may be common in certain areas. And we have had less specific questions before. $\endgroup$ – Renan Oct 6 '18 at 11:55
  • $\begingroup$ Mad, as a colloquium, is to broad and is archaic enough in it's usage here to require further clarification. Do you mean delusional, reduced risk aversion, pan-esthetic, or some other psycho reactive symptom? $\endgroup$ – pojo-guy Oct 6 '18 at 11:56
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    $\begingroup$ Given that LSD is the initials for the formal name of the chemical compound, the LSD was the same. However it was probably cut with different compounds. $\endgroup$ – pojo-guy Oct 6 '18 at 17:02
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Lead

From the wiki:

Lead poisoning can cause a variety of symptoms and signs which vary depending on the individual and the duration of lead exposure.Symptoms are nonspecific and may be subtle (...) Poisoning by organic lead compounds has symptoms predominantly in the central nervous system, such as insomnia, delirium, cognitive deficits, tremor, hallucinations, and convulsions.

Symptoms may be different in adults and children; the main symptoms in adults are headache, abdominal pain, memory loss, kidney failure, male reproductive problems, and weakness, pain, or tingling in the extremities.

Early symptoms of lead poisoning in adults are commonly nonspecific and include depression, loss of appetite, intermittent abdominal pain, nausea, diarrhea, constipation, and muscle pain. Other early signs in adults include malaise, fatigue, decreased libido, and problems with sleep. An unusual taste in the mouth and personality changes are also early signs.

The creepy thing about all of this is that supposedly the US once banned toys imported from China because many were coated in lead (because all the cheapest paints for plastic contain it), so kids wouldn't get poisoned. What this means is that in our world nowadays, specially in poor countries were there is a lot of oversight on this, lead poisoning is a common risk. The non-specificity of the symptoms makes it hard for people, mostly the poor and without access to public health care, to know what is happening to them.

You can get poisoned with lead by drinking contaminated water. An easy source of contamination are pipes that contain lead. Guess why plumbers are called plumbers (hint: check the periodic table). In ancient Rome people got contaminated by drinking from vessels made of lead.

Edit: still on lead ppisoning, I'm just going to leave this here:

Lead poisoning

Source: https://www.smbc-comics.com/comic/ai-3

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  • $\begingroup$ The thing about lead is that it is a long term contaminant, like the rest of the heavy metals. The OP's question isn't really clear as to the timeframe $\endgroup$ – nzaman Oct 6 '18 at 12:03
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'make him mad ...'

LSD comes to mind.

The American government, under CIA auspices, spent millions on trying to perfect LSD as a brainwashing drug.

Montreal was their major base of experimentation.

Victims of alleged LSD brainwashing experiments in Montreal plan to file lawsuit

They did succeed in making people mad, and wiping out their brain, but were not that successful in the reprogramming aspect.

EDIT

And I mean 'mad' in every mental illness form of the word. Schizophrenia, paranoia, PTSD symptoms, overbearing anxiety, dementia, you name the 'mad' mental illness tag, Cameron did it.

EDIT again

And here is a reference from TIME magazine.

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I have read unlimited news in which a person has knowingly laced the food items of a person with something to make him mad to...

(This is a "frame challenge" answer.)

fulfil an ill purpose like succession of property

That's mind control.

frustration due to failure in love etc.

And a love potion.

You are referring to magic potions, herbs, etc. They're all mumbo jumbo.

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  • $\begingroup$ Uh, you've never heard of mind altering drugs? $\endgroup$ – Davor Oct 6 '18 at 16:44
  • $\begingroup$ @Davor as mentioned in JustinThyme's answer, "but were not that successful in the reprogramming aspect." $\endgroup$ – RonJohn Oct 6 '18 at 17:03
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The general term you're looking for is psychotomimetic. This is a chemical which produces behavior mimicking psychosis. The classic along these lines is LSD, followed closely by PCP. Amphetamines can do the job, but usually in large doses over long time periods.

However, these chemicals have effects which are both well-known and temporary. So far as I know, there is nothing which can be counted on to produce permanent insanity within a short time.

If long-term dosage is permitted, then there are a number of candidates, generally heavy metals. Lead has been mentioned in another answer, and copper will do nicely as well. In Newton's Madness: Further Tales of Clinical Neurology, Harold Klawans writes of a patient, a young woman, who has been diagnosed with hebephrenia (a form of schizophrenia). He discovers that her problem is actually copper poisoning, in part from using a copper-based IUD for birth control.

He also writes of a young man with recurring flashbacks to a crime he committed while under the influence of PCP. The flashbacks are so intense, and so horrifying to the patient that he is essentially disabled. So PCP can have the effect you desire, but you can't count on it.

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