I feel like nothing is going to work better on large prey than a good set of teeth and strong jaws. If you look at almost all the large hunters, they use their jaw. Both on land and in the water (its a bit different in the water). I don't include in the air because I don't see a way for a bird to be able to hunt prey 10x larger than it while on flat terrain (no good air currents to help it gain altitude). It would expend so much energy and while on the ground it would be vulnerable to scavengers and other hunters or the so called large prey its hunting.
I would imagine the best way would be to be able to maul the preys throat, preventing it from breathing properly, severing major arteries to the head and letting it bleed out fairly quickly. Of course, the problem with larger animals is that they have larger necks, are usually taller and have thicker skin. So the second best way would be to exhaust it/bleed it out by making numerous cuts on its body.
You can watch videos of wolves, lions and other pack predators hunting larger animals. There are advantages to hunting as a pack and disadvantages. Firslty there is strength in numbers. You can fan out, trap and direct your prey. You can have multiple tries at taking down and injurying your prey, weakening them enough until you can overwhelm them. You can also have members sit out of a hunt, either because they are injured, raising young or otherwise unable to participate. Of course the disadvantage is that you have a much larger number of mouths to feed with the same prey. You also have several members that can distract the target while the others attack it.
The problem with solo hunting is that if your creature becomes sick, injured, pregnant or generally unwell it is faced with death straight away. Being low on energy and trying to recover can be risky. Being even lower on energy after you have recovered will lead to most of your hunts failing as you just won't have as much energy to use as before. The biggest issue with this is that big prey often develop deterrences and defences to protect themselves. Buffalo have horns. One unlucky stratch for a solo predator is a death sentence and since the animal is larger you cant just over power it. You need to weaken it first before making a killing blow.
Another suggestion people are making is using poison, venom or some sort of toxin. This wouldn't work too well for larger prey, especialy 10x larger prey. The toxin will take time to propagate and during this time your hunter is vulnerable to attack from a panicking prey. Just due to size, this can become a huge risk. A single stomp could end you and the prey collapsing on you will also likely just end you.
You can also look at the nature of hunters (Snakes) that utilize venom. They are often ambush predators which means they wait patiently for the prey to come near them. This means that they need to be well disguised and have a low metabolism to they don't waste unnecessary energy while waiting for the prey to come to them. The best way for them to ensure that is to be small so they won't be seen, or hide in large bodies of water so they can remain cool and not be seen. The issue with ambush hunters is that they can't just affort to hunt one type of prey. Since the prey needs to approach them, anything they can consume is good enough. Secondly, I don't think I've seen many cases of a ambush hunter taking down something 10x larger than it.
THe final point I want to make is that larger animals all tend to be herd animals. Large animals often don't have predators before their large size makes it extremely hard for predators to take them down and for it to be worth it. Since the large prey can't be hunted due to their size and the risk, hunters often go for their calves or babies who are significantly smaller and more vulnerable. To counteract this, the large animals stay in a herd to offer protection.
Basically, I'm saying Pack Hunters, built for endurance and multiple short bursts of speed, with really sharp and maybe replaceable/regrowable teeth. You wear the animal down over time and go for the killing blow once its too tired to retaliate. A prey 10x larger is a huge risk to hunt, so they need to be agile. It will be too large to take down instantly via any sort of body part or toxin and staying close and attached to it would be a huge risk to any hunter, so they will need to distract it, and dart in and out, making numerous small cuts and bites that build up over time.