Social alienation is your biggest problem and good makeup won't fix that.
After a few decades, you and your wife will be irrevocably 'other' to most humans on a social level. If you attempt to maintain your original identity, people will start to wonder who you are when you write "Age: 450 years". All those questions will get tiresome after a while (well, they would for me).
Say you have a set of 10 friends who are approximately your age now. In a few decades, they will want to stay home, enjoy good wine and talk about politics. Your wife and you will want to go do things because you'll have the physical vitality to do so. You also won't look or move like your friends anymore. Whether the divergence of the friendship is gradual over time or a sudden termination will depend on lots of factors. Even if you do somehow manage to maintain these friendships, all these friends will die. Either you retreat into the friendship of your spouse or you find new friends.
To younger people who more physically match your own appearance and abilities, your mental state will border on alien (perhaps more-so than humans who have aged normally). Your priorities may be radically different and your perspectives will certainly be different. You'll be in this weird place where your bodies are young but your minds are very old. Young people may bore you quickly while older people just won't accept you because you're too 'young'.
No matter how close you are to all your family members, all those relationships are going to end. How much emotional turmoil are you willing to deal with? Let's say that your favorite aunt gets cancer and is on her deathbed. You know full well that you can save her life and keep her around forever, if you share the secret of immortality. That's an easy situation that can get really sticky later.
What happens when it's your least favorite aunt who has cancer and you don't want them to live forever but your family members don't want that aunt to die? If it's known that you could have saved them but didn't, resentments that will never die could start there. You may not have the option of breaking ties with your family. Your resenting relatives may tell their children who tell their children to never ever forgive you.
Do you want to watch all your family members die, especially in light of knowing you could save them but choose not to? You will watch your grandchildren and great grandchildren die.
Eventually, you and your wife will be very wealthy. Maintaining physical comfort will be very easy after your investments pay-off in 30 years. Most people race to get enough savings to live off the interest before they can't work anymore. You don't have that problem. Investments that won't pay off for 50 years are acceptable because you've got eternity to wait.
There are many time-tried methods for preserving wealth. Trusts, inheritances, shell companies, and so on. Making sure you have a good place to inherit all your assets isn't hard, especially since you've got enough money to afford extremely good tax attorneys and accountants.
Immortality is such a strange place
Everything is boring. Everything changes but nothing changes. Preserving a specific lifestyle is impossible in a modern era. The world as a whole changes too fast. If you want to stay the same, you'll have to work increasingly hard to preserve your way of doing things. In 100 years, cell-phones may not be a thing. They weren't 100 years ago. It's far better to adapt to whatever the current circumstances. It's cheaper and provides a chance to avoid the tedium of existence by new novelties.
You can expect that the oldest aspects of human existence will persist. You'll still have and need friends. Acquiring food, shelter and clothing will take up some of your time (though if you're wealthy this will be a really small portion of your time, if you want it to.)