In space the most valuable resource is a very limited number of super advanced gateways that form a massive, galaxy spanning network with each other. Obviously, each major faction is going to try to acquire these gateways with EXTREME prejudice. For that reason, each empire builds massive space stations that anchor to these gateways and function as guardians. You want to come through a gateway? Fine, present your ID to the station commander and let him deactivate the multitude of weapons pointed at your current location. Of course if the ID doesn’t check out the offending ship will soon be reduced to a very fine cloud of space debris. This ensures that the gateways are able to both regulate traffic within each empire, and withstand assaults from hostile forces.
The gateways themselves are large rings about 50 miles across, though some are larger and some are smaller. Each gate connects to one other gate, but multiple gates can be in a single system. The current space empires cannot destroy or even damage gateways, and they cannot build new ones. The stations that protect each gateway are anchored to them and are capable of firing on any threat from any direction, and are linked to allied fleets, drones, satellites, and friendly planets. There is FTL travel and communication in this universe but the gateways are basically instantaneous travel between two points regardless of distance. In addition, “energy shielding” is present in this universe, but shields can be pierced or even broken entirely with enough force or the correct application of force.
So my question is what weaponry would be most effective on this station? Are we talking just rows upon rows of missiles or should the station have a more diversified arsenal? Bonus points for some kind of exotic weaponry or regular weaponry dialed up to 11. The threats they would be facing are varied, from small drones up to massive dreadnoughts, and even massive creatures that call space their home.