Is it possible to breed humans to create a group with no mental or physical deformities. And get to the point where this group of humans is also biologically more resistant to mutations that might cause physical and mental deformities. None of these individuals can have a genetic predisposition to any disease.
closed as primarily opinion-based by sphennings, kingledion, JBH, Justin Thyme, rek Jan 18 '18 at 3:24
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No, or, not naturally
In a natural environment mutations are all-but guaranteed to happen. This is one of the methods by which evolution occurs, which means that it is baked into our DNA. So it may be possible to reduce/eliminate mutation in humans, but not in a naturally breeding population.
Tight genetic control and embryo manipulation will need to be instituted via artificial means to make this possible.
This runs into the key issue with eugenics (as pointed out in the comments): the definition of a genetically perfect person is subjective.
To put it in more concrete terms, the definition of genetic perfection has evolved considerably in the last...all of human history. Ask a European from 1600 what a perfect person looks like and you are certain to get a different answer than an Egyptian in 2000 BC, or a South American in 1900, or any of us today in 2018.
On the one hand, we like to think that today we know better and have scientific ways of figuring out what genetic traits are better and worse and therefore our decisions will be correct. But...every other person in all of history thought the same thing.
Our definition of "perfect" is always changing. To assume that our perceived perfection of today comes from an objective viewpoint is hubris.
Philosophically/morally/historically/sociologically a perfect person does not exist and therefore cannot be made.
Scientifically, in absence of the viewpoints previously mentioned, it is possible, but not while maintaining natural reproduction.
No, not really.
It would require redesigning how the genome works. Currently we rely on genetic diversity and redundancy to handle mutations and adaptation. And that pretty much forces the possibility of genetic variability being high enough that it can cause at least some genetic disease. You'd essentially need to create an artificial genome that produces something that appears like a human but really isn't.
Even then preventing mutations would probably be prohibitively expensive. I think that somebody recently argued that such issues are mathematically inevitable for multi-cellular organisms. It was specifically about cancer and had some assumptions I was not entirely happy about but it does give some idea about the level of difficulty one should expect : very high.
And yes, I am basically giving the same answer enpaul did. I hope the rationale is different enough to have value.