When you say 'Best' do you mean 'best for the crew', 'best for operation of the ship', 'best for maximum use of space', or 'best for the author, in case the book is made into a film'?
Star Trek had 'normal' artificial gravity simply because it was much easier to film the series in 'normal' gravity.
But as we now know from ISS, a lack of gravity is really, really useful for utilizing every available bit of space in the ship. With no 'up' or 'down', and no 'falling out of cupboards', then storage lockers can be put on all of the walls, complete surround storage. So in terms of space utilization efficiency, no gravity is best.
But in terms of housekeeping, when suspended particles never move, except in the air flow, keeping the central room space empty requires a bit of gravity to attract everything to a surface. Thus, for housekeeping it makes sense to have a surround gravity. That is, every surface in the space has some gravitational attraction sufficient to keep things on the surface.
In terms of human health, are the inhabitants ever expected to return on-planet? If they are permanent spacers, then humans can do just fine in point 2 or point 3 gravity. Mars, for instance, would need no gravity enhancement in the living spaces.
But since inertia is always the same with or without gravity, the lower the gravity the slower the spacemen could move. Accelerating too fast means that, when they hit solid wall, they do so with a painful thump. So they would move very slowly to limit acceleration, and therefore minimize inertia. Having all of the outside surfaces be the gravitational attraction would perhaps ease the problem, because there would always be 'counter gravitational forces' in every direction.
However, gyms and such exercise and sports spaces would definitely want high 'up-down' gravitational fields. When jogging, for instance, you want sufficient gravity to allow high acceleration without inertial run-away, and you want the track to be 'down'. You want sufficient gravity to allow good friction between boot and tack surface.
To maximize sleeping surface, a round tube where bunks would be placed all around the outside, with minimal gravity around the outside to keep the occupants from drifting. In naval ships,the bunks are stacked four and five high to maximize sleeping space. Imagine if they could utilize top and bottom surfaces? That is, crew members face each other when sleeping.
But eating quarters and dining rooms? Definitely things work better when the table is down and your mouth is up. Makes food much easier to cut and stab.
Office-type quarters would require a constant up-down gravity field. Typing is rather difficult when every key press sends the typist backwards. Writing is hard when an over-emphatic pen stroke sends the writer flying off to the side. Fidgeting in the chair can launch one into an unintended trajectory. And squirming in a chair? Forget it, unless something is 'sticking' you to it.
However, I can foresee that perhaps the propulsion system would work best in no gravity. 'Containment vessels' are much easier to control when there is no gravity pulling on the object to be contained. Place the substance in the general area, it does not move. Turn on the containment field around it. No need for supports before the containment field is turned on.
So the bottom line. If you are really after 'best', and the technology allows it, different gravity on different surfaces in different parts of the ship would be 'best overall'. Say in the storage areas, no gravity; in the gyms, high gravity on the playing surface (perhaps 'dial-a-gravity' to increase the intensity of the workout); in sleeping quarters, mild gravity around the walls; in transit hallways, no gravity but lots of handholds, padding, and inertial shock absorbers at the ends; in the dining room, low gravity on the table; and in office-type areas, low gravity in an up-down orientation to allow paper to remain still in slight breezes, and people to stay sitting even while fidgeting.
And how about 'dial-a-gravity' special surfaces throughout the ship for housekeeping? Turn them up, way up, all the garbage gets attracted to them. Just wipe the surface off, and return to normal gravity situation. No more clutter, no more dust.