Some heterozygote advantages in humans are:
- People with sickle-cell trait are resistant to malaria, but people with sickle-cell disease tend to die young.
- Depending of the source we believe, people with one copy of a cystic fibrosis allele are immune to tuberculosis, or cholera, or typhoid fever (or two of them or all the three!) (it has been debunked).
- People with one copy the CCR5-delta 32 allele are resistant to AIDS, when they have two copies, they are immune to AIDS, but they are at higher risk for West Nile virus disease complications.
- People with Niemann-Pick disease type C are completely immune to ebolavirus-related hemorrhagic fever, and their heterozygous parents seem to be resistant against this disease caused by a filovirus.
So, I wonder what would a heterozygote advantage against coronaviruses (at least, the one responsible for severe acute respiratory syndrome and the one responsible for COVID-19) look like. I ask because I wonder if COVID-19 lasts for one decade and a half (15 years), could humans evolve to be more resistant to some infectious diseases.