Imagine a space cataclysm, where the Earth is hit by a deadly wave sterilizing all life of the bright side, but the dark side is more or less intact (at least the atmosphere and life are still in place).
The catch: it is not a momentary strike like a GRB, but a prolonged (and rather wide) beam of death. While the Earth rotates, all life is slowly cooked, except maybe for those in underground shelters (though I'd prefer them to die too) and submarines. The beam is wide enough, so the Earth, while moving through space, has enough time to rotate a couple of times before leaving the beam (or before the intensity drops down).
The survival: flying an aircraft from East to West, staying in the shadow long enough for the Earth to leave the deadzone (of for the beam to lose intensity).
The questions: what kind of source can emit such a beam? And what kind of aircraft can carry enough fuel to circumvent the Earth a couple of times, and provide the necessary velocity? Let's assume that we only have a few hours to prepare our craft (the other side is already toasted), so we can't reingeneer a passenger plane, for example, to carry fuel tanks in the passenger space; attaching standard outboard tanks is ok. Number of seats is unimportant for now.
The candidate: the Sun going supernova ("Inconstant Moon" by Larry Niven), but I'd prefer a more plausible scenario.