Timeline for Will a Humans Tolerance Keep Going Until Full Immunity?
Current License: CC BY-SA 4.0
25 events
| when toggle format | what | by | license | comment | |
|---|---|---|---|---|---|
| Jul 15 at 8:10 | comment | added | Going Durden | The drug would have to be very simple. The general rule of the thumb is that the more complex the drug, and more precise in its action, the quicker people grow immune or their tolerance increases beyond a plausible dose. Hence why people can "grow immune" to an antidepressant or anger-management medication within a year, but heroin or alcohol holds them captive for life. | |
| Sep 25, 2023 at 4:03 | comment | added | Loren Pechtel | @Blueriver While we obviously do not have immunity I rather suspect that there has been evolution about it. Cultures in which it was available all the time would have seen an evolutionary pressure against alcoholism that wouldn't apply in cultures that didn't know it or didn't have it all the time. | |
| Sep 23, 2023 at 21:10 | vote | accept | Saxionkin | ||
| Sep 23, 2023 at 1:51 | answer | added | Lawnmower Man | timeline score: 0 | |
| Sep 22, 2023 at 3:14 | comment | added | user458 | I think this is the kind of thing where you can choose. You already said soft science, so I imagine you'll just invent the chemical anyway. Check out this biology question about tolerance. It sits right in that valley between well known process and pop culture. | |
| Sep 22, 2023 at 1:18 | comment | added | Saxionkin | @Ryan_L its true that drunk people would be more likely to procreate, but the population is strictly monitored, people can't even date without applying to the government in order to figure out if they're too closely related. | |
| Sep 22, 2023 at 0:12 | comment | added | John | some people have the opposite reaction to sedatives, becoming hyperactive instead. See Paradoxical reactions. So it wont even work on everyone at first. | |
| Sep 21, 2023 at 20:00 | comment | added | Zags | Recommended viewing: Equilibrium (citizens on a daily dose of a sedative to prevent them from realizing the government is bad) | |
| Sep 21, 2023 at 19:56 | comment | added | GuilleOjeda | @Ryan_L you're right. And they're also more likely to forget about birth control, leading to an ever higher chance of reproducing. | |
| Sep 21, 2023 at 16:30 | comment | added | Ryan_L | @Blueriver since alcohol inebriation reduces social inhibition, natural selection seems likely to -increase- it, not decrease it. Drunk people are more likely to have sex, and thus are more likely to reproduce. | |
| Sep 21, 2023 at 14:48 | comment | added | Tom J Nowell | Are you looking for immunity within a persons lifetime, or immunity that develops via evolutionary pressure as people have children? | |
| Sep 21, 2023 at 14:47 | comment | added | Tom J Nowell | note that there are biological adaptations in humans for alcohol, including historic adaptations specific to regions that drank more alcohol than others, it's not so clear cut. | |
| Sep 21, 2023 at 14:20 | comment | added | Robbie Goodwin | How is this not dependent on which drug is used? | |
| Sep 21, 2023 at 11:33 | answer | added | Jani Miettinen | timeline score: 2 | |
| Sep 21, 2023 at 11:21 | answer | added | Peteris | timeline score: 1 | |
| Sep 21, 2023 at 8:52 | answer | added | Zoë Sparks | timeline score: 3 | |
| Sep 20, 2023 at 22:39 | comment | added | Saxionkin | @vinzzz001 that is a good idea, but much of the population needs to be near or completely neurotypical to be functional members of society and not be 'drains' of resources. Since there are limited resources and space, I can't have something that impedes the average brain and physical development since the city simply can't support those who can't work. otherwise my dystopic government would 100% feed people lead-laced cookies | |
| Sep 20, 2023 at 18:32 | comment | added | GuilleOjeda | If the drug is alcohol, we've empirically proven that several millenia isn't enough to develop immunity. | |
| Sep 20, 2023 at 12:57 | comment | added | vinzzz001 | Why rely on a drug that needs to be constantly be reapplied? Use something that causes targeted neurological damage early on enough on the people(children), with the desired effects, and it will affect them for the rest of their life. Take Lead for example: It is believed to lower IQ and cause learning disabilities, if assumed true -and our desired effects of keeping the people stupid- You can just feed it to the pregnant mothers as supplement, and the children will have a life long to enjoy it. Now invent some drug that can be applied to damage aggression response, and Bob's your uncle. | |
| Sep 20, 2023 at 10:58 | comment | added | Marco | Recent research on the rate of evolution has surprised some scientists. I can't find the original paper that I read about this, but a quick google revealed 2 related papers: royalsocietypublishing.org/doi/10.1098/rspb.2013.0211 , ncbi.nlm.nih.gov/pmc/articles/PMC2679939 . Echoing Kilisi, in a single generation, this is basically impossible -- however, depending on size and structure of the population, the rate at which people reproduce (pregnant at 15 or 30?) and the amount of mutagenic factors (radiation, chemical), there might be some interesting possibilities. | |
| Sep 20, 2023 at 10:13 | answer | added | Trioxidane | timeline score: 22 | |
| Sep 20, 2023 at 9:36 | answer | added | lupe | timeline score: 10 | |
| Sep 20, 2023 at 8:55 | history | became hot network question | |||
| Sep 20, 2023 at 1:45 | answer | added | Kilisi | timeline score: 5 | |
| Sep 20, 2023 at 0:54 | history | asked | Saxionkin | CC BY-SA 4.0 |