I have big troubles suspending my disbelief enough to accept a thing such as the described Anisotropy, one in which humans may still be able to live.

So follow me in a journey to the center of this Anisotropy

Terminology:

• "in the future direction" - towards the center of the Anisotropy
• "in the past direction" - opposite to the "future direction", away from the center of the Anisotropy

Start with the idea of a person that needs to be rescued. Most trivial case, the person is trapped in a concavity that doesn't allow her to advance towards the center. A rescuer can't see her until he is trapped in the same place.

Now, suppose the rescuer takes the absolutely blind risk of advancing in a concavity, just in case someone needs rescued there. So, he reaches the deadend too - what can he do?

Demolition charges? Yes, the rescuer may be able to throw one in the "towards center" direction and he will be safe from the shrapnel fragments (which cannot travel in the past). But doing so will kill whoever happens to be near or in "the near future" of the point the demolition charge explodes.

He can't even properly swing an axe - the back swing will "hit the past" - so that there's no "back half of the swing"; then the axe cannot be retracted after it hit something in "the future" direction, better hope one (half of a) blow is enough to clear the way.

Now that I think of it, anything with a functioning heart and lungs will be drawn towards the center.

The walls of the heart going "into the future" during the diastole can't contract back "into the past" during the systole. The only way for the heart to contract back is to drag the side in past towards the future direction. 2-3 heartbeats and the one living creature will need to... ummm, how to put it... follows one's heart into the future or else stop it from beating?
Pretty much the same with the lungs.

But, hang on, there's the Brownian motion too. Air molecules can't go into the direction of the past, right? Because if they do, one could communicate outside through sound and that's verboten.

Now, if my memory serves, the median speed of air molecules in their Brownian motion at normal temperature is between 300 m/s and 400 m/s. And the molecules can't go in the "past" direction.
Which means a wind of at least 200 m/s (averaging over half of the hemispheric solid angle oriented towards "the future"). So something like a wind of at least 720km/h, right?

But wait, that's not all. Recall now that the atoms/molecules of solid objects experience Brownian motion too. They themselves will be pushed "in the future"; granted, at a lower speed, but as inevitable as no time travel in the past.

Heh, one on top of the other, not only the Anisotropy is hostile to anything alive, but imagine what happens in the center of the Anisotropy with all that mass that is irresistible pulled towards a single point.

To my mind, a blackhole happens. I don't know what to hope for.

1. Should I wish the Anisotropy is never lifted until the blackhole mass gets past the "very energetic Hawking radiation" stage? May take a significant mass, something like the entire Everest range, and then it's only a few centuries until the BH goes boom

2. Should I wish the Anisotropy is never lifted? Well, that's a "Good-bye Earth", all one can hope the rate of Anisotropy substance accumulation is lower than the accretion speed of the BH at its center (and thanks God the BH is "in the future" and cannot affect the-past me directly)

3. should I wish for the Anisotropy is lifted ASAP and everything around be done and dusted under and explosion of Hawking radiation?