This is quite realistic and plausible. In fact, humans have already been doing essentially this over thousands of years of selective breeding. Dogs have been bred selectively to enrich for certain qualities like size, strength, intelligence, and sociability. Adding genetic engineering into the mix will allow this process to happen even faster, as traits can be more reliably selected and purified, rather than selectively breeding animals over many generations.
Since all of these qualities are enriched versions of already-existing dog biology, this is very well within the realm of possibility. Adding wings or gills or something decidedly un-doglike would be more of a challenge, but selectively improving already-existing qualities should be relatively more straightforward.
Crossbreeding with a wolf is also completely plausible, as dogs and wolves are interfertile, meaning their offspring are themselves fertile. So long as your genetic engineering isn't so drastic as to create an entirely new species, it's totally plausible that one of these dogs could mate with a wolf and have lineage of multiple generations in the wild.