Apart from chemical adaptations, the bigest problems I see are the spinal cord and knees. Even after centuries of evolution, modern humans often suffer from abrasions and damage to the cartilage in the knee joint or spinal disks.
In an environment of increased gravity, people would suffer from typical joint related old-age diseases at a younger age. Or their bodies would malform at a young age. A possible physical adaptation could be to revert to a quasi quadrupedal walk like chimpanses and gorillas. For that you would need longer arms and shorter legs, so the proportions of humans have to change quite a lot.
If they stick with the upright walk, the hips would probably become wider and stronger to offer better support for the entrails. A narrowing of the birth chanal would pose severe risks for any mother-to-be.
Edit 1
The thought of medieval corsets just came to my mind. In contrast to 18th century corsets that resulted in a wasp-waist, medieval corsets were used to support the back of hardworking people like housewives, soldiers and miners. If your people used corsets they wouldn't have to adapt too much physically.
Edit 2
Another rather funny but maybe realistic idea is to use crutches in times of high gravity and leaving them at home at times of low gravity. The regular use of cruthes would have an impact on their cultural accessoirs and behavior. Since one or both of your hands are occupied, to carry items around you need backpacks or bags with long straps that can be worn over the shoulder.
The social duties of people would differ greatly depending on their age: (abbreviations HG = High Gravity; LG = Low Gravity)
- Infants / small children won't do much during HG but compensate by excessive playing during LG
- Older children and juveniles are expected to carry stuff around and do most of the work during HG (since they don't suffer from abrasions in their joints yet) and have to tame the infants / small children during LG.
- Young adults have their mid-life-crisis at 25 - 30, when they notice the first joint aches and have to contemplate using a crutch or not
- Adults try to cope as best as they can in HG but have to get as much work done as they can in LG
- Elderly need assistance during HG and probably avoid standing up and walking as much as possible. LG is the time when they can feel somewhat younger again and help in controlling the infants / small children.
Concerning blood flow to the brain you could take giraffes as an example. Standing tall, their hearts have to pump blood all the way to the brain, but while drinking, they have to lower their head to the water level, resulting in a dangerous rush of blood. They have a sponge-like appendage to the brain that absorbs the excess blood and keeps them from passing out or bursting blood vessels in the brain.