There would be two somewhat different issues - one with acceleration, and one with running at speed.
Let's start with running. 65 mph is a very high speed for a bipedal creature. Your giant would have to push the ground much stronger than a normal sprinter just to compensate for air's resistance. Next problem is due to giant's big weight. The weight is 3-4 times more than normal. At the same time, feet surface is only 2-2.5 times large than normal (square-cube law, sorry). So, I would expect that during normal running the amount of ground pressure would be 1.5-3 times higher compared to a regular sized human.
That should be not an issue when running on hard surfaces like stone, but moving to dirt, grass, sand and mud should present a problem for your giant. Slowing effects of the soft surfaces would be disproportionally higher for a giant.
But the real problem would be acceleration. Cruising at speed has little requirements for the traction, but changing the speed (accelerating, slowing down and turning) puts athlete's shoes to a real test. If you played or watched games like football on a grass field, you might have noticed how the dirt is flying from players' feet at critical moments. It is becoming important to wear spiked shoes like cleats, because friction alone is not sufficient for adequate traction. You just can't play the same game when wearing sneakers, even good ones.
These traction problems would multiply for a giant runner. He would be having a very difficult time starting, stopping or maneuvering. Running on dry stone for him would be like running on wet stone for a normal person, and wet stone for him would feel like ice. Spiked shoes will become a necessity if he needs to run on dirt or grass. Interestingly, worst terrains like mud would actually provide better traction, so while the giant would be sliding in a thick mud, he would be sliding almost like a normal person.